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P1‐025: Cerebral Perfusion as an Imaging Biomarker of Presymptomatic Genetic Frontotemporal Dementia: Preliminary Results from the Genetic Frontotemporal Dementia Initiative (GENFI)
Author(s) -
Mutsaerts Henri J.M.M.,
Rohrer Jonathan D.,
Thomas David L.,
Cash David M.,
Vita Enrico,
Nicholas Jennifer M.,
Swieten John C.,
Dopper Elise G.P.,
Jiskoot Lize C.,
Minkelen Rick,
Rombouts Serge A.R.B.,
Dick Katrina M.,
Bocchetta Martina,
Cardoso M. Jorge,
Espak Miklos,
Mead Simon,
Black Sandra E.,
Freedman Morris,
Keren Ron,
Rogaeva Ekaterina,
Tang-Wai David F.,
Tartaglia Maria Carmela,
Laforce Robert,
Tagliavini Fabrizio,
Tiraboschi Pietro,
Redaelli Veronica,
Prioni Sara,
Grisoli Marina,
Galimberti Daniela,
Scarpini Elio,
Arighi Andrea,
Fumagalli Giorgio G.,
Rowe James,
Coyle-Gilchrist Ian,
Graff Caroline,
Fallström Marie,
Jelic Vesna,
Öijerstedt Linn,
Andersson Christin,
Thonberg Håkan,
Lilius Lena,
Finger Elizabeth,
Shoesmith Christen,
Rademakers Rosa,
Warren Jason D.,
Ourselin Sebastien,
Fox Nick C.,
Rossor Martin N.,
Knight Joanne,
MacIntosh Bradley J.,
Masellis Mario
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.772
Subject(s) - frontotemporal dementia , cerebral blood flow , dementia , grey matter , medicine , biomarker , neuroimaging , perfusion scanning , cardiology , imaging biomarker , oncology , pathology , psychology , magnetic resonance imaging , neuroscience , disease , perfusion , white matter , radiology , psychiatry , genetics , biology
Background Frontotemporal dementia (FTD) is a common cause of early onset dementia. While three genetic mutations are responsible for the majority of genetic FTD, imaging biomarkers that predict symptom onset are needed1. Recent work shows volumetric changes several years before the predicted age at disease onset2. Herein, we extend on this work by investigating whether perfusion patterns derived from non-invasive arterial spin labeling (ASL) MRI can be used as an early functional neuroimaging biomarker of presymptomatic genetic FTD. Methods Data were drawn from the GENetic Frontotemporal dementia Initiative (GENFI)2. From the first GENFI data freeze (n=220), 168 subjects had 3T ASL from which this analysis considers only the presymptomatic carriers and controls (n=144, Table 1). Cerebral blood flow (CBF)-maps were scaled to a mean grey matter (GM) CBF of 50 mL/100g/min per ASL sequence (four different ASL sequences were used) and registered to SPM12 3D T1 GM segmentations that were registered to MNI using DARTEL. In pre-selected ROIs associated with FTD, we investigated the effects of mutation status and years to expected age of disease onset on CBF, accounting for gender and family membership as fixed and random covariates. ROI CBF-values were corrected for partial volume fractions. Results Years to expected age of disease onset (p<0.007) was more correlated with CBF than age (p<0.1) alone. Although there was on average no CBF difference between carriers and non-carriers (p>0.1), there was an interaction effect between mutation carrier status and years to expected age of disease onset on CBF (Table 2). This interaction effect was significant for all ROIs except for the parietal and occipital cortices, anterior cingulate and putamen with the strongest effects being seen in the insula and the caudate nucleus (Figure 1). Conclusions CBF decreased as individuals approached the expected age of disease onset and this CBF decrease was accelerated in the presymptomatic mutation carriers compared to controls, in key regions implicated in FTD. These preliminary findings demonstrate the potential utility of non-invasive perfusion MRI as an early biomarker for genetic FTD. References 1. Montine et al., Neurology 2014 2. Rohrer et al., Lancet Neurol 201