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P1‐023: Antemortem Occipital Periventricular White Matter Hyperintensities Predict Cerebral Amyloid Pathology at Autopsy
Author(s) -
Marnane Michael,
Aljawadi Osama,
Mortazavi Shervin A.,
Li Jennifer,
Keller Connor,
Kim Angela,
Feldman Howard H.,
Mackenzie Ian,
Robin Hsiung Ging-Yuek
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.770
Subject(s) - neuropathology , pathology , autopsy , hyperintensity , medicine , dementia , occipital lobe , progressive supranuclear palsy , frontotemporal lobar degeneration , white matter , hippocampal sclerosis , alzheimer's disease , magnetic resonance imaging , atrophy , temporal lobe , frontotemporal dementia , disease , radiology , psychiatry , epilepsy
L+). Cut-off points were derived optimizing sensitivity and specificity in discriminating AMYcontrols from AMY+ AD patients. Results: Forty-one patients were designated as SNAP using crosssectional and 22 using longitudinal measures (overlap1⁄412). No patient converted to dementia after 24 months. In addition, 123 were classified as AMY+NEU/C+ and 86 AMY+NEU/L+ (overlap1⁄463) with the first group showing a higher conversion rate (41 vs 31%). The highest conversion rate was observed for those positive on both neurodegeneration measures (49%). The opposite pattern was observed in the 77 patients designated as AMY+NEU/Cand 114 as AMY+NEU/L(overlap1⁄454), with the first group showing a lower conversion rate (16 vs 23%). Thus, when using a crosssectional measure for neurodegeneration, 78% of the converters were placed in the AMY+NEU+ group compared to 59% with a longitudinal measure. Sixty-nine were AMY-NEU/Cand 88 AMY-NEU/L(overlap1⁄459). No difference in conversion was observed (1.4-1.7%). Conclusions: Considerable differences in prevalence were observed when defining NEU+ and NEUgroups based on cross-sectional versus longitudinal data. For the SNAP groups no difference was observed in conversion to dementia, and in this respect it is unclear which measure is more appropriate to define SNAP. Perhaps both measures capture neurodegenerative change, but reflect different rates of injury to the hippocampus. Interestingly, for the AMY+NEU+ group a cross-sectional neurodegeneration measure was more closely linked to conversion to dementia than a longitudinal one.