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O4‐07‐06: Revisiting, Revising and Refining the Natural History of Ab Deposition and its Effects on Neurodegeneration and Cognitive Decline in Sporadic Alzheimer's Disease
Author(s) -
Villemagne Victor L.,
Burnham Samantha,
Bourgeat Pierrick,
Dore Vincent,
Brown Belinda M.,
Laws Simon M.,
Salvado Olivier,
Rainey-Smith Stephanie R.,
Maruff Paul,
Macaulay S Lance,
Martins Ralph N.,
Ames David,
Masters Colin L.,
Rowe Christopher C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.648
Subject(s) - medicine , neuropsychology , cognitive impairment , nuclear medicine , psychology , disease , cognition , psychiatry
c 2 1⁄419.6, p<0.001; HABs: c1⁄433.5, p<0.001, Figure 2). Subjects with high-striatal Ab at baseline are more at-risk for longitudinal memory decline, longitudinal hippocampal atrophy, and tau deposition than subjects with low-striatal Ab, even among subjects with high-cortical Ab (Table 2). Conclusions:Both datasets provide evidence that striatal Ab accumulation occurs after neocortical Ab, at later disease stages. Striatal Ab is a risk factor for memory decline, hippocampal atrophy, and tau deposition, making it a potentially useful biomarker for tracking disease progression. Further work is ongoing to determine the potential added value of striatal Ab for predicting cognitive decline in preclinical stages.