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O4‐06‐06: The Impact of Anosognosia and Anosodiaphoria on the Prediction of Progression from Mild Cognitive Impairment to Alzheimer's Disease
Author(s) -
Munro Catherine E.,
Donovan Nancy J.,
Amariglio Rebecca,
Papp Kate V.,
Marshall Gad A.,
Rentz Dorene M.,
Pascual-Leone Alvaro,
Sperling Reisa A.,
Vannini Patrizia
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.642
Subject(s) - anosognosia , dementia , logistic regression , psychology , memory clinic , cognition , amnesia , disease , cognitive decline , memory impairment , medicine , audiology , psychiatry , clinical psychology
involved in self-referential processes as well as functional disconnection between these regions (Perrotin et al. 2015). The present study aims at extending these findings by better understanding the neural correlates of anosognosia in the prodromal stage of AD. Thus, here we used regional brain metabolism [FDG-PET] to unravel the metabolic correlates of anosognosia in patients with amnestic mild cognitive impairment (aMCI) and subsequently resting state fMRI [rs-fMRI] to investigate the intrinsic connectivity disruption between brain regions. Methods: Thirty-one subjects (mean age: 74.1; CDR: 0.5) with aMCI were included. All subjects underwent resting state 18-F fluorodeoxyglucose positron emission tomography (FDG-PET) for glucose metabolism measurement and resting state fMRI for intrinsic connectivity measurement. An anosognosia index was obtained by calculating discrepancy scores between subjective and objective memory scores. Voxelwise correlations between anosognosia and neuroimaging data were conducted. All analyses were controlled for multiple comparison using pFDR 1⁄40.05. Results: Anosognosia in aMCI patients correlated with reduced glucose metabolism in posterior cingulate (PCC) cortices and hippocampus (Figure 1). Intrinsic connectivity analyses revealed a significant association between anosognosia and attenuated functional connectivity between the PCC seed region and orbitofrontal cortex (OFC) as well as bilateral inferior parietal lobes (IPL, Figure 2). Conclusions: These findings provide further evidence implicating cortical midline structures involved in awareness of memory deficits. MCI patients with anosognosia showed reduced metabolism as well as disconnection between OFC, PCC and hippocampus, brain regions vulnerable to changes in early Alzheimer’s disease, and therefore could be at increased risk of developing dementia. O4-06-05 MCI DIAGNOSIS: LESS IS MORE Liesbeth Aerts, John D. Crawford, Nicole A. Kochan, Megan Heffernan, Brian Draper, Julian N. Trollor, Perminder S. Sachdev, Henry Brodaty, Dementia Collaborative Research Centre, University of New SouthWales, Sydney, Australia; 2 Centre for Healthy Brain Ageing, UNSW, Sydney, Australia; 3 Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia; Academic Department for Old Age Psychiatry, Prince of Wales Hospital, Randwick, Australia; 5 Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia; 7 University of New South Wales, Sydney, Australia; 8 Centre for Healthy Brain Ageing UNSW Australia, Sydney, Australia; Dementia Collaborative Research Centre ABC, UNSWAustralia, Sydney, Australia. Contact e-mail: l.aerts@unsw.edu.au