O4‐05‐04: Examining Dose‐Specific Outcomes in the Skill‐Building Through Task‐Oriented Motor Practice (STOMP) Intervention for Dementia

ter the intervention with dual tracer F-FDG and C-acetoacetate PET. Cerebrospinal fluid (CSF) was collected at baseline and after each intervention and assayed for AD biomarkers (Ab42 and total tau) with INNO-BIA-Alzbio3. Results: Global C-acetoacetate uptake decreased after the lowfat diet intervention (Fig 1 A Baseline and Fig 1 B Post-Lowfat Diet) and increased after the ketogenic diet intervention (Fig 1C Baseline and Fig 1D Post-Ketogenic Diet), whereas no changes were observed for F-FDG after either diet. Interestingly, CSF total tau increased with the ketogenic diet (p<0.05), with a similar trend noted for Ab42 (p1⁄40.08). Furthermore, the increase in Ab42and tau biomarkers was correlated (r1⁄4, p1⁄40.002). No biomarker changes were observed after low fat diet intervention. Conclusions: Ketogenic diet intervention enhanced brain ketone utilization in MCI and prediabetes, and produced correlated increases in CSF total tau and Ab42. Future investigation is needed to examine the relationship of these effects to changes in cognition.