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O4‐01‐06: Ab+ Clinically Normal Participants with Elevated Tau Show Greatest Decline in the Preclinical Alzheimer’s Disease Cognitive Composite
Author(s) -
Mormino Elizabeth C.,
Papp Kate V.,
Schultz Aaron P.,
Hanseeuw Bernard J.,
Munro Catherine E.,
Jaimes Sehily Y.,
Meneide Tamy-Fee,
Kilpatrick Emily P.,
Aghjayan Sarah L.,
Jonas Victoria H.,
Kirn Dylan,
Jackson Jonathan D.,
Amariglio Rebecca,
Rentz Dorene M.,
Sperling Reisa A.,
Johnson Keith
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.611
Subject(s) - cognitive decline , cognition , neuropsychology , medicine , dementia , psychology , disease , recall , pet imaging , audiology , oncology , positron emission tomography , neuroscience , nuclear medicine , cognitive psychology
nance imaging (MRI; 80.58 6 112.6 d AV-1451—PiB difference; 98.95 6 119.7 d AV-1451—MRI difference), with images transformed to a common space. We calculated each subject’s mean AV-1451 and PiB uptake values within 87 regions of interest (ROI), and a global cortical PiB value. We examined all pairwise ROI PiB—AV-1451 partial correlations for strength and significance to identify inter-tracer, interregional association patterns (covaried for age, sex, and global gray matter volume). Results: Pairwise ROI analysis demonstrated positive and negative PiB—AV-1451 associations (Figure 1). Importantly, strong (p < .01) positive partial correlations were identified between temporal AV-1451 and PIB in extensive temporal and extra-temporal cortical ROIs. We also found less frequent positive associations of regional PiB with frontoparietal AV-1451 (Figure 2). For AV-1451 ROIs where uptake was strongly predicted by PiB ROI (e.g., temporal, frontal AV-1451 uptake), these strong correlations were present regardless of PiB ROI location. Overall correlation strengths were visualized on a brain template (Figure 3). Conclusions:Ab and tau pathology, measured using PiB and AV-1451 PET, show significant associations among cognitively normal elderly. In particular, increased PiB uptake both within and outside temporal lobes correlates with increased temporal lobe AV-1451 uptake. In addition, the correlations between Ab and tau accumulation do not appear to be explained by the location of Ab accumulation. These results suggest a regional vulnerability of certain brain regions (e.g. temporal lobe) to tau accumulation regardless of where Ab accumulates.

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