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O3‐08‐04: Tau Covariance Patterns in Alzheimer's Disease Patients Resemble Intrinsic Connectivity Networks in Young Adults
Author(s) -
Ossenkoppele Rik,
Schonhaut Daniel R.,
Brown Jesse,
O'Neil James P.,
Janabi Mustafa,
Baker Suzanne L.,
Schöll Michael,
Kramer Joel,
Gorno Tempini Marie-Luisa,
Miller Bruce,
Seeley William W.,
Jagust William J.,
Rabinovici Gil D.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.552
Subject(s) - voxel , lingual gyrus , neuroscience , superior frontal gyrus , middle frontal gyrus , posterior cortical atrophy , default mode network , resting state fmri , covariance , voxel based morphometry , functional connectivity , psychology , white matter , functional magnetic resonance imaging , medicine , magnetic resonance imaging , pathology , dementia , mathematics , disease , statistics , radiology
tion between EC-T807 and diffusion on global cognition was examined. All analyses were corrected for age, education and gender. Results: EC-T807 binding predicted MD, AD and RD values in HC and FC (all ps <0.03). No associations were found for diffusivity values in the other tracrs. EC-Tau predicted cognition (p1⁄40.002). There was no main effect of diffusion values on global cognition, however, the interaction of EC-T807 by diffusion values predicted global cognition scores for the HC model (p<0.05 for MD (Fig.2), AD and RD). No interaction was found for other tracts. Conclusions: Given the limits of our data, EC tau pathology in healthy older individuals affects primarily the HC. White matter integrity of the HC itself does not predict cognition, but in the context of higher EC tau, it does. This suggests that EC tau drives HC connectivity loss leading to cognitive decline. The HC bundle connects medial temporal with parietal cortices, areas vulnerable to amyloid. Further research will examine the contribution of amyloid.