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O3‐08‐03: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Author(s) -
Jacobs Heidi I.L.,
Schultz Aaron P.,
Amariglio Rebecca,
Hedden Trey,
Papp Kate V.,
Perea Rodrigo D.,
Rentz Dorene M.,
Sepulcre Jorge,
Sperling Reisa A.,
Johnson Keith
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.551
Subject(s) - fornix , white matter , entorhinal cortex , neuroscience , cognitive decline , psychology , cingulum (brain) , hippocampal formation , hippocampus , context (archaeology) , cognition , dementia , medicine , biology , fractional anisotropy , magnetic resonance imaging , disease , radiology , paleontology
ducted by two reviewers on articles published prior to 2016. Studies were included if they (1) used seed-based or Independent Component Analysis rs-fMRImethods, (2) investigated functional connectivity between patients (AD orMCI) and healthy controls (HC), and (3) reported coordinates of between-group comparisons. Networkand voxel-based quantitative meta-analysis was performed on four group comparisons: MCIHC, ADHC. Network-level statistics were conducted using functional brain parcellations at two resolutions (7 and 36 networks), derived from an independent dataset. Voxel-based activation likelihood estimate (ALE) was also conducted to assess the spatial consistency of coordinates across studies. For both analyses, statistical significance was determined via permutation testing using randomly distributed foci. Results: Thirty-five studies, containing 1,363 participants (MCI1⁄4352, AD1⁄4382 and HC1⁄4629), 99 contrasts (MCIHC1⁄412, ADHC1⁄419), and 406 significant foci, were included. Data used in our study have been made available on brainspell.org. Network-based meta-analytic results revealed aberrant functional brain connectivity in both MCI and AD cohorts. Relative to HC, MCI subjects demonstrated consistent hypo-connectivity in an attentional frontoparietal network, while AD patients exhibited hypoand hyper-connectivity in the default-mode (DMN) and salience networks, respectively (Figure 1). At the voxel level, ALE results showed only modest spatial overlap of connectivity abnormalities across studies, mainly limited to the DMN. Conclusions:Only a few resting-state networks, including the DMN, were found to be consistently involved in AD and MCI, which may reflect either high spatial specificity of AD pathology or a selection/reporting bias. Although network-based meta-analysis led to significant findings, high variability in the localization of connectivity alterations was obvious in voxel-based analysis, likely due to small sample sizes and heterogeneous methods in the current literature.