Premium
O3‐08‐01: Grey Matter Connectivity is Associated with Time to Clinical Progression in Mild Cognitive Impairment, Independent of Amyloid Status
Author(s) -
Tijms Betty M.,
Kate Mara ten,
Gouw Alida A.,
Teunissen Charlotte E.,
Barkhof Frederik,
Scheltens Philip,
van der Flier Wiesje M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.549
Subject(s) - grey matter , dementia , hazard ratio , psychology , proportional hazards model , medicine , cohort , alzheimer's disease , neuroscience , disease , oncology , magnetic resonance imaging , white matter , confidence interval , radiology
upper and lower body flexibility) (p<0.001). In contrast, people with dementia demonstrated improved agility (p<0.001) whereas care partners did not (p1⁄40.52). Participants also reported a significant increase in weekly frequency, duration and intensity of physical activity (p<0.01). However, participants reported no change in physical activity self-efficacy (p1⁄40.20) and a small but significant decline in mood (p1⁄40.001) and knowledge of the health-implications of physical and social activity (p1⁄40.002). Conclusions:Participation in MIM was associated with significant improvements in physical function and physical activity for both people with dementia and their care partners. However, participants reported poorer mood after the program. Whether this change is a result of the program or unrelated changes over time is unclear. MiM is a promising program for the physical health of people with dementia and their care partners.