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O3‐03‐02: MCI STATUS, AMYLOID AND TAU BIOMARKERS, AND COMPOSITE COGNITIVE IMPAIRMENT SCORES ARE ASSOCIATED WITH COGSTATE PERFORMANCE IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION
Author(s) -
Racine Annie M.,
Koscik Rebecca L.,
Clark Lindsay R.,
Mueller Kimberly D.,
Berman Sara Elizabeth,
Nicholas Christopher R.,
Asthana Sanjay,
Blennow Kaj,
Zetterberg Henrik,
Jedynak Bruno,
Bilgel Murat,
Christian Bradley T.,
Carlsson Cynthia M.,
Johnson Sterling C.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.519
Subject(s) - neuropsychology , psychology , neuropsychological assessment , oncology , cognition , medicine , alzheimer's disease neuroimaging initiative , clinical psychology , alzheimer's disease , disease , psychiatry
(memory, executive function, depression, and apathy) was examined in each diagnostic sub-group. Results: In the hierarchical regression analyses, memory, executive function, and apathy accounted for an additional 14.6 – 20.1% of the variance in function over and above the variance accounted for by age, education, and MMSE. Memory and function were significantly correlated for individuals diagnosed with dementia (AD: r 1⁄4 -0.22; non-AD: r 1⁄4 .035). Executive function and function were significantly correlated only when measured by the Stroop test in the non-AD group (r 1⁄4 -0.32). Apathy and function were significantly correlated in the cognitively intact (r 1⁄4 0.47), MCI (r 1⁄4 0.30), and AD groups (r 1⁄4 0.37). Depression and function were only significantly correlated in the cognitively intact group (r1⁄4 0.34). Conclusions:Cognitive rehabilitation strategies need to be expanded beyond memory, particularly for individuals withmild cognitive impairment. Apathy has a stronger association with daily function than low mood, and executive function as measured by the Stroop test has the strongest relationship with function in a non-AD dementia sample.