O3‐02‐03: Regional Association between Cortical Volumes and Imaging Tau Pathology Using  18 F‐AV1451 And  18 F‐THK5351 | Zendy

Dore Vincent | Zendy; Bourgeat Pierrick | Zendy; Fripp Jurgen | Zendy; Macaulay S Lance | Zendy; Masters Colin L. | Zendy; Ames David | Zendy; Martins Ralph N. | Zendy; Salvado Olivier | Zendy; Rowe Christopher C. | Zendy; Villemagne Victor L. | Zendy

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O3‐02‐03: Regional Association between Cortical Volumes and Imaging Tau Pathology Using 18 F‐AV1451 And 18 F‐THK5351

Author(s) -

Dore Vincent,

Bourgeat Pierrick,

Fripp Jurgen,

Macaulay S Lance,

Masters Colin L.,

Ames David,

Martins Ralph N.,

Salvado Olivier,

Rowe Christopher C.,

Villemagne Victor L.

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.514

Subject(s) - neocortex , pons , nuclear medicine , cortex (anatomy) , chemistry , pathology , neuroscience , medicine , psychology

gitudinal). [F]FDG intensity was normalized to the pons. Baseline global cortical [F]Florbetapir and mean parietal [F]FDG SUVR, as well as 2yr annualized percent change (APC) in global [F]Florbetapir were extracted. Baseline and 2-year hippocampal volumes (HV) were estimated using Freesurfer v5.1. Step-wise linear models predicting cortical or MTL [F]AV-1451 SUVR with the following predictors were assessed: cortical [F]Florbetapir SUVR, annual percent change (APC) in cortical [F]Florbetapir SUVR, mean parietal [F]FDG SUVR, HV, APC in HV, diagnosis (control or MCI/AD), age, gender, and time between scans. Results:Mean cortical [F]AV-1451 uptake was predicted only by diagnosis and cross-sectional mean cortical [F]Florbetapir SUVR. However, MTL [F]AV-1451 uptake was predicted by both mean cross-sectional cortical [F]Florbetapir uptake and cross-sectional HV. Conclusions: Overall, [F]AV-1451 uptake (representative of tau deposition) was predicted by the extent of cortical amyloid deposition ([F]Florbetapir uptake) approximately three years prior. Hippocampal atrophy may interact with this process. [1] Risacher et al. (2015) Alzheimer’s & Dementia, (11): 1417.

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