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O2‐13‐05: CSF Markers of Inflammation and Alzheimer's Disease Pathogenesis in the Cognitively Intact Prevent‐Ad Cohort
Author(s) -
Breitner John C.S.,
Poirier Judes,
Town Terrence,
Rosa-Neto Pedro,
Tremblay-Mercier Jennifer,
Weitz Tara M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.470
Subject(s) - medicine , pathogenesis , cohort , biomarker , dementia , oncology , disease , placebo , immunology , gastroenterology , pathology , biochemistry , chemistry , alternative medicine
cant decrease of human Tau multimers (HT7/HT7 setup), as well as a significant decrease of a misfolded Tau (MC-1/HT7 setup) in a total brain fraction.A trend to decrease humanTau phosphorylated at pS396 in different brain fractions was also observed. ACI-35 treatment significantly improved the rotarod performance in both the transgenic hTauP301S-Tg model and the AAV-TauP301S spreading model. Conclusions: The study demonstrated that active immunization with ACI-35 significantly decreased human pathological Tau species in different brain fractions and ameliorated the clinical phenotype in two different mouse models of tauopathy.