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O2‐09‐05: Coronary Artery Bypass Graft Surgery and Dementia Risk in the Cardiovascular Health Study
Author(s) -
Kuzma Elzbieta,
Airdrie Jac,
Littlejohns Thomas J.,
Lourida Ilianna,
Thompson-Coon Jo,
Lang Iain A.,
Scrobotovici Monica,
Thacker Evan,
Fitzpatrick Annette L.,
Kuller Lewis H.,
Lopez Oscar L.,
Longstreth W.T.,
Ukoumunne Obioha,
Llewellyn David J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.446
Subject(s) - medicine , hazard ratio , dementia , interquartile range , proportional hazards model , coronary artery disease , cardiology , diabetes mellitus , confidence interval , surgery , disease , endocrinology
ations between lipid levels and total or regional MD or FA were generally null, with a few exceptions. Additional adjustment for WMH slightly attenuated, but did not nullify observed associations of BP or midlife blood glucose with measures of FA or MD (e.g., difference in standardized FA per 10 mm Hg increase in midlife systolic BP before WMH adjustment: -0.056, 95%CI: -0.091, -0.021; after WMH adjustment -0.048, 95%CI: -0.076, -0.019). Conclusions: Hypertension and diabetes may lead to poor or declining cognition through mechanisms that disrupt microstructural integrity. DTI measures of FA and MD provide unique information on underlying processes not captured by measures of WMH.