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O2‐09‐04: Changes in Retinal Signs and their Associations with Cognitive Performance: The Multi‐Ethnic Study of Atherosclerosis (MESA)
Author(s) -
Hughes Timothy M.,
Espeland Mark A.,
Sink Kaycee M.,
Baker Laura D.,
Craft Suzanne,
Rapp Stephen R.,
Fitzpatrick Annette L.,
Sharrett A Richey,
Luchsinger Jose A.,
Klein Ronald,
Klein Barbara E.K.,
Wong Tien Yin
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.445
Subject(s) - medicine , retinal , dementia , memory span , cognitive decline , cognition , diabetic retinopathy , effects of sleep deprivation on cognitive performance , cognitive test , diabetes mellitus , ophthalmology , audiology , cardiology , disease , psychiatry , endocrinology , working memory
ations between lipid levels and total or regional MD or FA were generally null, with a few exceptions. Additional adjustment for WMH slightly attenuated, but did not nullify observed associations of BP or midlife blood glucose with measures of FA or MD (e.g., difference in standardized FA per 10 mm Hg increase in midlife systolic BP before WMH adjustment: -0.056, 95%CI: -0.091, -0.021; after WMH adjustment -0.048, 95%CI: -0.076, -0.019). Conclusions: Hypertension and diabetes may lead to poor or declining cognition through mechanisms that disrupt microstructural integrity. DTI measures of FA and MD provide unique information on underlying processes not captured by measures of WMH.