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O2‐02‐05: A Mechanism for Enhanced Exosome Secretion in the Brain of Down Syndrome Patients
Author(s) -
Perez-Gonzalez Rocio,
Levy Efrat
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.403
Subject(s) - exosome , microvesicles , western blot , secretion , endosome , biology , extracellular , microbiology and biotechnology , amyloid precursor protein , escrt , extracellular vesicle , chemistry , intracellular , alzheimer's disease , biochemistry , medicine , microrna , gene , disease
We also conducted in vitrostudies investigating effects of isolated human GI bacteria in converting dietary fibers and select polyphenol products into biologically available SCFAs and phenolic acids that are effective in inhibiting Ab aggregation. Results:We found several phenolic acids that potently inhibited Ab aggregation. We also found significant differences among GI microbiota from different healthy human donors in converting dietary polyphenols into these bioactive phenolic acids and in further metabolic degradation of these phenolic acids. Ongoing studies are investigating effects of individual SCFAs in Ab aggregation and the efficacy of GI microbiota from different human donors in the generation (and degradation) of these SCFAs. Conclusions: Intestinal microbiota may help protect AD, in part, by supporting the generation of phenolic acids and SCFAs that interferes with the formation of toxic soluble Ab aggregates. Presence of interpersonal differences in the human gut microbiota may lead to interpersonal variation to benefit from the protective effects of dietary fiber and polyphenols in AD. Outcomes provide critical information for developing probiotics to help prevent and/or treat AD.