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O1‐09‐01: Genomewide Linkage Analysis Identifies Novel Candidate Genes for Alzheimer’s Disease
Author(s) -
Ahmad Shahzad,
Amin Najaf,
Blue Elizabeth,
van der Lee Sven J.,
Nato Alejandro Q.,
Sohi Harkirat,
Wang Bowen,
Boerwinkle Eric,
DeStefano Anita L.,
Wijsman Ellen,
Duijn Cornelia M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.341
Subject(s) - genetics , pedigree chart , genetic linkage , biology , linkage (software) , single nucleotide polymorphism , gene , computational biology , genotype
ages 65-79 years. At original enrollment into the trials, women had been randomly assigned to 0.625 mg/d conjugated equine estrogens (CEE) for those with prior hysterectomy (mean 7.1 years), CEE with 2.5 mg/day medroxyprogesterone acetate for thosewith an intact uterus (mean 5.4 years), or matching placebos. Cognitive assessments included telephone evaluations of global cognition, verbal memory, working memory, verbal memory, and executive function. Results: Hormone therapy, when prescribed to women aged 50-54 years, had no significant long-term post-treatment effects on cognitive function or change in cognitive status over time. When prescribed to older women, it was associated with long term mean (SE) relative decrements (standard deviation units) in global cognitive function of 0.081 (0.029) SD, working memory of 0.070 (0.025) SD, and executive function of 0.054 (0.023) SD, all p<0.05. These decrements were relatively stable over time. Findings did not vary depending on the hormone therapy regimen or pre-study use. Although mean intervention effects were small, the largest were comparable in magnitude to those seen during the trial’s active intervention phase. Conclusions: CEE-based hormone therapy delivered near the time of menopause provides neither cognitive benefit nor detriment. If administered in older women, it results in small decrements in several cognitive domains that remain for many years.