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O1‐06‐02: Wwii Combat Exposure is not Associated with Late‐Life Cognitive Decline, Dementia, Neuropathologic Alzheimer’s Disease, or Other Neuropathologic Abnormalities: the Honolulou‐Asia Aging Study (HAAS)
Author(s) -
White Lon R.,
Willis Emy A.,
Mackintosh Margaret,
Launer Lenore J.,
Edland Steven D.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.324
Subject(s) - dementia , autopsy , medicine , cognitive decline , hippocampal sclerosis , cohort , neuropathology , alzheimer's disease , atrophy , psychology , disease , gerontology , psychiatry , temporal lobe , epilepsy
scores indicates that predicted cognitive changes over 8 years is close to observed ones. For example, for patients with mild cognitive impairment (MCI) at baseline and stable until dropout, disenrollment, or death, the correlation coefficient between predicted and observed scores is 0.82. For patients who are normal at baseline but transition to Alzheimer dementia, the correlation coefficient is 0.73. Conclusions:We tested the feasibility of a machine learning algorithm to discern patterns of long-term cognitive change, and then to predict ADAS-Cog scores and annual changes over 8 years. We are in the process of revising our methods with the goal of translating our research method to settings in which data relevant to cognitive status and decline are less rich than ADNI in high-salience predictive power.