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EC‐01‐02: Structure of Γ‐Secretases and Implications for Drug Development
Author(s) -
Bai Xiao-chen,
Rajendra Eeson,
Yang Ganghui,
Shi Yigong,
Scheres Sjors
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.288
Subject(s) - amyloid precursor protein secretase , proteolysis , amyloid precursor protein , presenilin , transmembrane protein , chemistry , protease , cleavage (geology) , biophysics , transmembrane domain , gamma secretase , drug discovery , helix (gastropod) , biochemistry , stereochemistry , microbiology and biotechnology , membrane , biology , enzyme , alzheimer's disease , disease , receptor , medicine , paleontology , pathology , fracture (geology) , ecology , snail