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P4‐268: Changes of SIRT1/MTOR Signaling Pathways in Senile Mice's Hippocampus With Caloric Restriction
Author(s) -
Wang Rong,
Ma Lina
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2379
Subject(s) - caloric theory , calorie restriction , medicine , hippocampus , hippocampal formation , endocrinology , immunohistochemistry , blot , pi3k/akt/mtor pathway , calorie , biology , signal transduction , biochemistry , gene
Morris Water Maze and T2*MRI, respectively. Results:The telmisartan dose used in this study (0.5 mg/kg/day) did not impact blood pressure, and had minimal effect on fasting blood glucose and glucose tolerance. In addition, our initial results suggest that telmisartan treatment did not have an effect on Morris Water Maze performance. We do have evidence, however, that the instance of vascular events is decreased in telmisartan-treated mice compared with age-matched controls. Conclusions:It is intriguing that animals treated with telmisartan display a reduced number of MRi-detectable vascular incidents, especially since there is apparently no change in cognitive function. This study is ongoing. In the future, we plan to examine the effect of telmisartan treatment on other parameters of vascular function, at both the cellular and tissue level, and to investigate AT1R blockade as a potential therapeutic for preexisting vascular conditions in the dbAD mice.