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P4‐229: How are Cognitive Impairment Patients Being Diagnosed?
Author(s) -
Hu Xiaohan,
Jones Eddie,
Wood Robert,
Black Christopher M.,
Ambegaonkar Baishali M.,
Khandker Rezaul Karim
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2321
Subject(s) - medicine , dementia , demographics , cognitive impairment , disease , pediatrics , affect (linguistics) , statistical significance , demography , psychology , communication , sociology
changes were observed in the same regions. Alzheimer disease pathology was also present in two members of the family. Conclusions: The E200K-129M haplotype is the most common form of fCJD while there are only five reported cases of E200K-129V haplotype in the literature. The presence of intraneuronal PrP immunopositive inclusions appears to be a consistent finding in subjects with the E200K mutation; however, their morphology needs to be further investigated with high resolution microscopy. Acknowledgements: P30AG010133; NIH P01 AG-14359, Charles S. Britton Fund and CDC UR8/CCU515004.