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P4‐216: Reduction in Hippocampal Volume is Associated With Age and Memory Deficits in Retired Professional Football Players
Author(s) -
Misquitta Karen,
Dadar Mahsa,
Tarazi Apameh,
Ebraheem Ahmed,
Multani Namita,
Khodadadi Mozhgan,
Goswami Ruma,
Wennberg Richard,
Tator Charles,
Green Robin,
Colella Brenda,
Davis Karen,
Mikulis David,
Collins Louis,
Tartaglia Maria Carmela
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2308
Subject(s) - concussion , verbal memory , football , psychology , audiology , medicine , cognition , poison control , psychiatry , injury prevention , environmental health , political science , law
LAB with the Hammers template was used to delineate regions of interest (ROIs) on a co-registered T1 weighted MRI scan. Next, regional time-activity curves were generated by projecting these ROIs onto the dynamic PET frames. These curves were analyzed using reversible and non-reversible single and two tissue compartment models, both with and without a blood volume parameter. Results: The reversible single tissue compartment model (1T2k_VB) was the preferred model for all HC. For AD patients, however, model preference shifted towards a reversible two tissue compartment model (2T4k_VB), as shown in Figure 1, especially for ROIs with high distribution volume (VT > 9 mL cm ). In HC, a good correlation (R 1⁄4 1.00, slope 1⁄4 1.01) was observed between VT derived from 1T2k_VB and 2T4k_VB, indicating that 2T4k_VB is the best model for group comparisons. Figure 2 shows 2T4k_VB derived VT for several (AD specific) ROIs. Figure 2 also suggests that cerebellum may be used as a reference region in AD. Conclusions:The relationship between model preference and VT suggests that (higher) tau load may be reflected by a second tissue compartment. Although further studies are needed, it seems that consistent VT values across subjects can be obtained using a reversible two tissue compartment model.