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P4‐205: Impact of Apathy on DMN Functional Connectivity Alterations in Alzheimer’s Disease
Author(s) -
Won Wangyoun,
Lim Hyun Kook,
Lee Chang Uk
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2297
Subject(s) - apathy , default mode network , functional connectivity , posterior cingulate , precuneus , psychology , anterior cingulate cortex , neuroscience , superior frontal gyrus , disease , cortex (anatomy) , medicine , functional magnetic resonance imaging , cognition
nounced for the animals subtest (rho1⁄4-0.385, p<0.0005 uncorrected for multiple comparisons). Testing standard blood/urine laboratory values revealed a positive correlation of MTL SUVR with HB1C (rho1⁄40.285, p1⁄40.009) and a tendency for positive correlation with the HOMA-IR insulin resistance index (rho1⁄40.207, p1⁄40.074). Pons-scaled FDG uptake in an AD-signature meta-ROI (comprising posterior cingulate / precuneus and parietotemporal cortex) showed a positive correlation with the CERADplus animals z-score (rho1⁄40.329, p1⁄40.002) but was not associated with HB1C or HOMA-IR.Conclusions:These findings suggest that hypermetabolism in the mesial temporal lobe is associated with poorer performance in some cognitive domains in hospitalized geriatric patients.