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P4‐196: Clinical Impacts of Cortical Superficial Siderosis in Patients With Clinically Diagnosed Cerebral Amyloid Angiopathy
Author(s) -
Jang Young Kyoung,
Kim Hee Jin,
Kim Yeo Jin,
San Lee Jin,
Lee Juyoun,
Jang Hyemin,
Na Han Kyu,
Seo Sang Won
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2288
Subject(s) - superficial siderosis , cerebral amyloid angiopathy , dementia , cognition , neuropsychology , medicine , confounding , magnetic resonance imaging , siderosis , cognitive decline , neuroimaging , psychology , pathology , radiology , disease , psychiatry
follow up in addition to the baseline PIB and AV45. PIB and AV45 data were processed using our standard pipeline to obtain mean cortical target to reference ratio (MCSUVR) for comparison. Results:PIB and AV45MCSUVRs are strongly correlated for the baseline data (r1⁄40.90), and regional spread function (RSF) partial volume correction increased the correlation (r1⁄40.93). When two similar randomly selected subsets of baseline data were used to construct the linear model that project PIB MCSUVR to AV45 MCSUVR, the projected MCSUVR were significantly different (p<0.00001) between the two models in the longitudinal cohort. The follow-up to baseline correlation was slightly higher for PIB (r1⁄40.96) than AV45 (r1⁄40.94), both of which were higher than PIB to AV45 correlation. The projected AV45 MCSUVR change (from PIB) were significantly different in magnitude than measured AV45 MCSUVR change (p1⁄40.04); and the projected AV45 MCSUVR changes were also significantly different using the two linear model. Conclusions: While PIB and AV45 based amyloid measurements had reasonably high correlations, the subtle difference between the two make them difficult to harmonize, at least using a linear model. Further investigation is ongoing on this issue.