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P4‐177: MCI Trial Enrichment Using MRI Hippocampus Texture
Author(s) -
Sørensen Lauge,
Igel Christian,
Nielsen Mads
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2269
Subject(s) - magnetic resonance imaging , alzheimer's disease neuroimaging initiative , neuroimaging , biomarker , medicine , hippocampus , brain size , sample size determination , hippocampal formation , cognition , cognitive decline , cognitive impairment , psychology , nuclear medicine , dementia , radiology , disease , psychiatry , chemistry , statistics , biochemistry , mathematics
functions such as working memory (Figure 2). The uSEM analysis further revealed that MCI and AD network connectivity are changed considerably from that of CN, specifically between the primary olfactory cortex (POC), lateral prefrontal cortex (LPC) and the orbitofrontal cortex (OFC) (Figure 3). Conclusions: The functional activity and connectivity during odor processing in the central olfactory system are altered dramatically as revealed by fMRI and the uSEM analysis, indicating its involvement in AD functional pathology. Thus, olfactory fMRI can potentially be a non-subjective functional marker for early diagnosis and quantitative evaluation of AD.