Premium
IC‐P‐193: Examining Amyloid and TAU Inter‐Regional PET Association Patterns in Cognitively Normal Older Adults
Author(s) -
Lockhart Samuel N.,
Schöll Michael,
Mellinger Taylor J.,
Swinnerton Kaitlin N.,
Bell Rachel K.,
O'Neil James P.,
Janabi Mustafa,
Baker Suzanne L.,
Jagust William J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.224
Subject(s) - pittsburgh compound b , magnetic resonance imaging , nuclear medicine , psychology , medicine , pathological , dementia , pathology , disease , radiology
performed [F]AV1451 covariance analyses in 27 AD patients (Table 1) and seed-based functional connectivity in 1000 young healthy adults (18-35 years, www.neurosynth.org), based on 4 atrophy peak voxels identified in a previous paper on distinct clinical variants of AD. These peak voxels were located in right middle occipital gyrus [rMOG] for posterior cortical atrophy, left superior temporal gyrus [lSTG] for logopenic variant PPA, right middle frontal gyrus [rMFG] for early-onset AD, and left posterior cingulate gyrus [lPPC]) as the common denominator. For [F]AV1451, we generated SUVR images for the interval between 80-100 minutes post-injection, and used the mean SUVR values from 4mm spheres drawn around the peak voxels as independent variables in whole-brain voxelwise covariance analyses of [F]AV1451 uptake (p<0.05 FWE corrected, no covariates). For resting-state fMRI data, we used the peak voxels as seeds to extract intrinsic connectivity maps. We then performed visual inspection of the covariance and functional connectivity maps to assess their overlap, and goodness-of-fit analyses for [F]AV1451 covariance maps against 8 predefined functional network templates.Results:Therewas a striking overlap between [F]AV1451 covariance and intrinsic connectivity maps (Figure 1). Goodness-of-fit showed strongest overlap between rMOG and the higher visual network, lSTG and the language network, rMFG and the executive control network, and lPCC with the posterior default mode network (Table 2). Conclusions: The spatial pattern of tau observed in AD patients does resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks.