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P4‐135: Neuropsychiatric Symptoms of Mild Cognitive Impairment Predicting Progression to Dementia in the Rosas Cohort
Author(s) -
Kiyasova Vera,
Soto Maria,
Galtier Stephanie,
Guignot Isabelle,
Lala Françoise,
Sastre Nathalie,
Delrieu Julien,
Ousset Pierre Jean,
Pueyo Maria,
Vellas Bruno
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2226
Subject(s) - apathy , dementia , irritability , cohort , clinical dementia rating , memory clinic , depression (economics) , anxiety , medicine , psychology , cohort study , cognitive impairment , alzheimer's disease , disease , psychiatry , economics , macroeconomics
were more likely converted to dementia (1 year 16.7 vs 37.5 vs 69.2%; 2 year 33.3 vs 50.0%, and 76.9%) (Figure.1).The difference in conversion rates were significant at both 1 year (p<0.001) and 2 year (p1⁄40.004). The positive likelihood ratio (LR+) of mixed type MCI converting to dementia was 15.63 and 9.16 at 1 and 2 year respectively when comparing with MCI of Alzheimer’s etiology. Conclusions: The overall dementia conversion rate of MCI is high and up to 40% in 2 years. Subtype of MCI has significant impact on rates of progression to dementia.
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