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IC‐P‐191: [F‐18]THK5351 Retention is Associated with the Progression of Brain Atrophy in Patients with Alzheimer’s Disease
Author(s) -
Okamura Nobuyuki,
Ishiki Aiko,
Furukawa Katsutoshi,
Harada Ryuichi,
Tomita Naoki,
Furumoto Shozo,
Tashiro Manabu,
Yanai Kazuhiko,
Arai Hiroyuki,
Kudo Yukitsuka
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.222
Subject(s) - atrophy , neurodegeneration , parahippocampal gyrus , temporal lobe , neuroscience , medicine , temporal cortex , cortex (anatomy) , hippocampus , pathology , disease , psychology , epilepsy
tionships in whole-brain maps, and included the same covariates as whole-brain analyses. Results: Whole-brain maps relating AV1451 signal and ROI slope at a threshold of p<0.05, uncorrected, showed widespread negative associations between parahippocampal thinning and AV1451, especially in temporal regions. ROI analyses showed significant relationships between parahippocampal thinning and AV1451 in bilateral inferior temporal (left: t(92)1⁄4-2.60,p1⁄40.011; right: t(92)1⁄4-2.72,p1⁄40.0077) and middle temporal cortex (left: t(92)1⁄4-3.65,p1⁄40.00043; right: t(92)1⁄43.27,p1⁄40.0015), and left entorhinal (t(92)1⁄4-2.73,p1⁄40.0076), isthmus cingulate (t(92)1⁄4-3.34,p1⁄40.0012), and posterior cingulate cortex (t(92)1⁄4-2.57,p1⁄40.012). Entorhinal thinning was associated with temporal pole AV1451 (left: t(92)1⁄4-3.07,p1⁄40.0028, right: t(92)1⁄4-3.27,p1⁄40.0015).Maps of AV1451 also showed relations between posterior cingulate thinning and precuneus AV1451 (left: t(92)1⁄4-2.67,p1⁄40.0090, right: t(92)1⁄4-3.33,p1⁄40.0012). Conclusions: Parahippocampal cortex thinning over a prior three-year period predicts a widespread pattern of increased tau pathology, especially in the temporal lobe. Entorhinal and posterior cingulate thinning predicted increased temporal and parietal AV1451, respectively, but the maps were more localized. This is consistent with autopsy studies, which show tau pathology and neurodegeneration largely restricted to the temporal lobe in cognitively normal elderly individuals. Further study is ongoing to determine the relationship between AV1451 and prospective changes in cortical thickness.