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P4‐121: Neuroprotective Effect of Serum Uric Acid on Alzheimer’s Disease is Mediated by Brain Metabolism Change
Author(s) -
Ye Byoung Seok,
Ha Woo Seok,
Lee Jae Jung,
Lee Yoonju,
Lee Phil Hyu,
Sohn Young H.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2212
Subject(s) - medicine , cognitive decline , uric acid , alzheimer's disease , endocrinology , alzheimer's disease neuroimaging initiative , amyloid (mycology) , psychology , dementia , disease , pathology
Other biomarkers included routine AD markers (Ab1-42, hTau and pTau181P, INNOTEST, Fujirebio Europe, Belgium) and NF-light (UmanDiagnostics, IBL International GmbH, Germany). Results: FTLD-GRN patients had the lowest serum and CSF progranulin levels of all groups, which determined the significances when comparing FTLD-TDP and FTLD-tau groups (p<0.05) and when comparing FTLD, AD and controls (p<0.02). Progranulin levels in CSF and serum were significantly correlated in all FTLD subgroups except C9orf72 repeat expansions carriers. CSF levels of markers for neurodegeneration (hTau and NF-light) were highest in FTLD-GRN patients as compared to other FTLD-subgroups (Table 1). A cox hazard regression analysis (corrected for age at onset) in another cohort of dementia patients without motor neuron disease, showed a mean disease duration of 5.6y62.6y inGRN carriers (n1⁄440) and 8.2y65.0y in C9orf72 carriers (n1⁄430) (p1⁄40.051) (Figure 1). Conclusions: Our results confirm that CSF and serum progranulin levels can reliably identify GRN mutation carriers in a dementia cohort. The increased CSF levels of tau and NF-light chain in GRN mutation carrying FTLD patients suggest more neurodegeneration in this subgroup.GRN carriers indeed have a shorter disease duration than C9orf72 carriers. P4-121 NEUROPROTECTIVE EFFECT OF SERUM URIC ACID ON ALZHEIMER’S DISEASE IS MEDIATED BY BRAIN METABOLISM CHANGE Byoung Seok Ye, Woo Seok Ha, Jae Jung Lee, Yoonju Lee, Phil Hyu Lee, Young H. Sohn, Yonsei University College of Medicine, Seoul, South Korea; Yonsei University College of Medicine, Seoul, Republic of Korea; 3 Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. Contact e-mail: romel79@gmail.com