P4‐104: HSV‐1 Avidity Index: A Possible Biomarker for Monitoring the Evolution of Mild Cognitive Impairment to Alzheimer’s Disease | Zendy

Agostini Simone | Zendy; Mancuso Roberta | Zendy; Calabrese Elena | Zendy; Hernis Ambra | Zendy; Nemni Raffaello | Zendy; Clerici Mario | Zendy

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P4‐104: HSV‐1 Avidity Index: A Possible Biomarker for Monitoring the Evolution of Mild Cognitive Impairment to Alzheimer’s Disease

Author(s) -

Agostini Simone,

Mancuso Roberta,

Calabrese Elena,

Hernis Ambra,

Nemni Raffaello,

Clerici Mario

Publication year - 2016

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2016.06.2195

Subject(s) - avidity , dementia , disease , medicine , herpes simplex virus , biomarker , pathogenesis , pathological , atrophy , immunology , cognition , antibody , oncology , virus , psychiatry , biology , biochemistry

pram. Furthermore, SI reduced the levels of BDNF, serine473-phosphorylated Akt (active form) and serine-9-phosphorylated GSK-3b (inactive form) with no significant changes in the levels of total GSK-3b and Akt in the dorsal hippocampus, but not in the posterior cingulate. Conclusions:Our results suggest that decreased synaptic plasticity in cognition-associated regions might contribute to SI-induced cognitive deficits, and citalopram could ameliorate these deficits by promoting synaptic plasticity mainly in the prefrontal cortex, dorsal hippocampus and ventral hippocampus. The BDNF/Akt/GSK-3b pathway plays an important role in regulating synaptic plasticity in SI rats.

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