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IC‐P‐185: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Author(s) -
Jacobs Heidi I.L.,
Schultz Aaron P.,
Amariglio Rebecca,
Hedden Trey,
Papp Kate V.,
Perea Rodrigo D.,
Rentz Dorene M.,
Sepulcre Jorge,
Sperling Reisa A.,
Johnson Keith
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.216
Subject(s) - fornix , white matter , cingulum (brain) , entorhinal cortex , external capsule , neuroscience , psychology , diffusion mri , cognitive decline , fractional anisotropy , cognition , hippocampal formation , hippocampus , medicine , magnetic resonance imaging , dementia , disease , radiology
WHITEMATTERCONNECTIVITYONCOGNITIVE DECLINE IN HEALTHY OLDER INDIVIDUALS DEPENDS ON ENTORHINALT807 BINDING Heidi I. L. Jacobs, Aaron P. Schultz, Rebecca Amariglio, Trey Hedden, Kate V. Papp, Rodrigo D. Perea, Dorene M. Rentz, Jorge Sepulcre, Reisa A. Sperling, Keith Johnson, Massachusetts General Hospital, Athinoula A. Martinos Centre for Biomedical Imaging, Harvard Medical School, Boston, MA, USA; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; 3 Center for Alzheimer Research and Treatment, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 5 Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA; 7 Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Division of Molecular Imaging and Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 9 Athinoula A. Martinos Center for Biomedical Imaging and the Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Contact e-mail: hjacobs@mgh.harvard.edu