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P4‐061: Amyloid Precursor Protein C‐Terminal Cleavage Resulting in the Toxic C31 Peptide: Stimulation of Cleavage with Cerevastatin and Inhibition and Cell Viability Rescue Using Small Molecules
Author(s) -
Poksay Karen S.,
Sheffler Douglas J.,
Campagna Jesus,
Spilman Patricia,
Mullenix Michael,
Bredesen Dale E.,
Cosford Nicholas D.P.,
John Varghese
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2151
Subject(s) - cleavage (geology) , proteolysis , intracellular , amyloid precursor protein , caspase , caspase 3 , programmed cell death , microbiology and biotechnology , chemistry , biology , biochemistry , apoptosis , alzheimer's disease , enzyme , disease , pathology , fracture (geology) , medicine , paleontology