Premium
P4‐054: Genetic Variants of Micrornas and Insights Into Amnestic Mild Cognitive Impairment
Author(s) -
Chen Lu Hua,
Fan Yan Hui,
Ping Kao Patrick Yu,
Yin Ho Deborah Tip,
Song You-Qiang,
Chu Leung Wing
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2144
Subject(s) - microrna , dementia , allele , single nucleotide polymorphism , genotyping , disease , oncology , biology , medicine , psychology , bioinformatics , genetics , genotype , gene
imputation in the 103,067 individuals using a “cosmopolitan” reference panel of the full set of the 1000 Genomes project genotypes to generate genotypic probabilities for variants not directly assayed. The Apoe4 allele was imputed with an r1⁄40.92. EMR diagnoses of dementia, Alzheimer’s disease(AD), MCI and subjective memory complaints (SMC) were collected from 1996-2015. APOE allele frequencies were examined across all cognitive impairment phenotypes versus controls by racial/ethnic groups. We examined the association between E4 (3/4 and 4/4) and phenotypes with odds ratios (OR). Results: The mean age of the sample at collection was 62 years. E4 was present in 22% controls, 32%Dementia, 41% AD, 32%MCI and 31% SMC for Europeans (Table 1). AD risk was 2.5-fold increased among those with an E4 allele versus without, and dementia, MCI, and SMC risk were all 1.7 fold increased in those with E4 versus those without in Europeans; findings were similar across all racial/ethnic minority groups (Table 1). Conclusions: This is one of the largest efforts to date evaluating E4 and EMR records of subjective memory complaints and diagnoses of dementia andMCI phenotypes. EMR phenotypes and subjective memory complaints in this diverse cohort are increased for those with E4, suggesting future applications for identifying those at increased AD risk harnessing large-scale electronic data combined with biospecimens.