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P4‐048: Convergent Analysis of Endophenotypes in Progressive Supranuclear Palsy
Author(s) -
Allen Mariet,
Wang Xue,
Younkin Curtis S.,
Serie Daniel,
Sun Zhifu,
Burgess Jeremy D.,
Baheti Saurabh,
Kouri Naomi,
Nguyen Thuy,
Lincoln Sarah,
Malphrus Kimberly G.,
Carrasquillo Minerva M.,
Zou Fanggeng,
Chai High-Seng,
Murray Melissa E.,
Schellenberg Gerard D.,
Younkin Steven G.,
Crook Julia E.,
Ordog Tamas,
Asmann Yan W.,
Dickson Dennis W.,
Ertekin-Taner Nilufer
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2137
Subject(s) - progressive supranuclear palsy , endophenotype , genome wide association study , expression quantitative trait loci , biology , genetics , single nucleotide polymorphism , snp , gene , genotype , neuroscience , atrophy , cognition
entrainment to light and mealtime. To evaluate sleep, mice received cranial implants of a modular EEG/EMG electrode grid (Pinnacle Systems). This allowed both rapid eye movement (REM) and non-REM phases to be monitored. We were particularly interested in slow wave sleep (i.e., Phase 3 of non-REM), which is essential for clearing misfolded proteins contributing to AD pathogenesis (e.g., amyloid-beta; Ab), suggesting a bidirectional relationship between sleep and AD pathology (Xie et al., 2013; Ju et al., 2014). Results: Sleep and circadian rhythm data collection is ongoing and will be collected at 6, 9, and 12 months of age. Behavioural analysis will be followed by probing the molecular processes underlying the circadian phenotype. Conclusions: The APP/PS1 mouse model of AD may be a useful model for developing interventions to improve sleep and circadian synchrony.