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P4‐037: The First Multitep‐Based DNA Vaccine Targeting n‐Terminus of Pathological TAU Induces Strong Immune Responses and Reduces TAU Pathology in TAU Transgenic Mice
Author(s) -
Davtyan Hayk,
Chen Wesley W.,
Zagorski Karen,
Davis Joy,
Petrushina Irina,
Cribbs David H.,
Agadjanyan Michael G.,
Blurton-Jones Mathew,
Ghochikyan Anahit
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2126
Subject(s) - dna vaccination , elispot , immunogenicity , epitope , immune system , immunology , vaccination , antibody , genetically modified mouse , immunotherapy , splenocyte , medicine , biology , transgene , cd8 , immunization , biochemistry , gene
TARGETING N-TERMINUS OF PATHOLOGICAL TAU INDUCES STRONG IMMUNE RESPONSES AND REDUCES TAU PATHOLOGY IN TAU TRANSGENIC MICE Hayk Davtyan, Wesley W. Chen, Karen Zagorski, Joy Davis, Irina Petrushina, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan, Institute for Molecular Medicine, Huntington Beach, CA, USA; University of California Irvine, Irvine, CA, USA; 3 University of California, Irvine, Irvine, CA, USA. Contact e-mail: hayk.davtyan@immed.org