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P4‐012: Intraventricular Insulin Treatment Prevents Against Central STZ‐Induced Impairment in Spatial Learning and Memory
Author(s) -
Moosavi Maryam,
Bahramian Abbas,
Rastegar Karim
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2101
Subject(s) - morris water navigation task , streptozotocin , amnesia , insulin , memory impairment , medicine , saline , diabetes mellitus , endocrinology , psychology , hippocampus , cognition , psychiatry
amyloidogenic processing of amyloid precursor protein (APP), as well as a reduction in aggregation and fibril formation of Ab. In addition, intranasal insulin also promoted neurogenesis in APPswe/PS1dE9 mice. Conclusions:The present study unveils the mechanisms underlying the beneficial effects of intranasal insulin on Ab pathologies in vivo for the first time. Our results support that intranasal insulin can be a very promosing therapeutics for the prevention and treatment of AD.