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IC‐P‐176: Diabetes Mellitus Alters Brain Iron Metabolism in Cognitive Impaired Patients: Quantitative Susceptibility Mapping (QSM) Study
Author(s) -
Moon Won-Jin,
Moon Yeon Sil,
Han Seol-Heui
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.207
Subject(s) - globus pallidus , putamen , quantitative susceptibility mapping , white matter , medicine , hyperintensity , thalamus , basal ganglia , cardiology , magnetic resonance imaging , endocrinology , neuroscience , psychology , radiology , central nervous system
studied, only NODDI derived orientation dispersion index (ODI) showed significant increase in fornix (cres) of SCD subjects (Fig. 2). Other diffusion metrics such as DTI and q-space analysis were not significant (Table 1).Compared to DTI and q-space analysis, NODDI derived diffusion metrics appear more sensitive to WM changes in SCD in AD-relevant regions. In addition, the increase of dispersion index suggests the organization of WM fibers may deteriorate in these early stages whereas the axonal density (measured by NODDI intra-cellular volume fraction) remains stable. Conclusions:This initial study suggests that advanced diffusion imaging such as HYDI and NODDI may be more sensitive to early stage AD compared to classical DTI approaches. References: Wu (2007) Neuroimage, Zhang (2012) Neuroimage, Oishi (2008) Neuroimage.