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P3‐396: IMPROVING TIMELY DIAGNOSIS AND MANAGEMENT OF DEMENTIA IN THE HEALTH CARE SETTING
Author(s) -
Dorbin Cornelya D.,
Parker Monica W.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.2062
Subject(s) - dementia , medicine , gerontology , confusion , cognition , health care , cognitive impairment , population , family medicine , continuing medical education , disease management , cognitive decline , disease , continuing education , psychology , psychiatry , medical education , environmental health , pathology , psychoanalysis , economics , economic growth , parkinson's disease
/ 33 female) were included in the study. Participants were randomly allocated to a 12-week individualised aerobic exercise program intervention (n 1⁄430) or a 12 week waiting control group. Assessment included psychometric testing (memory, attention, executive function), assessment of movement-related parameters and a cardiopulmonary exercise test (CPET). H MRSI was applied to measure metabolic profiles. Furthermore, structural MRI was used to quantify grey matter volume. Participants successfully passing all assessments were randomised to either receive intervention during the subsequent 12 weeks (intervention group) or after a waiting period of 12 weeks (control group). Twelve weeks after allocation, all participants were reassessed, using identical methods. Results: Multivariate repeated measures ANOVAs did not reveal significant effects of the aerobic exercise intervention on cognitive outcomes (p > 0.5), nor on grey matter volumes (p > 0.5). With regard to the metabolic profiles, there was a trend towards changes induced by active training. The most prominent effect was an increase in NAA/tCho for the intervention group (interaction of group x time: p1⁄4 0.037), whereas no changes were observed for the control group (interaction of group x time p 1⁄4 0.637) Conclusions:Aerobic exercise seems to induce metabolic changes in the brain of older adults. The increase in NAA/tCho following regular aerobic exercise was not associated with improved cognitive function. A possible explanation could be the relatively small sample size (n 1⁄4 30 in each group), resulting in a lack of statistical power to detect subtle effects of aerobic exercise on cognition.