Premium
IC‐P‐173: Utility of PMOD Image Quantification Software for Processing [ 11 C]PIB and [ 18 F]Flutemetamol Images for SUVR Quantitation on The Centiloid Scale
Author(s) -
Battle Mark R.,
Buckley Chris J.,
Smith Adrian,
Van Laere Koen,
Vandenberghe Rik,
Lowe Val J.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.204
Subject(s) - nuclear medicine , pittsburgh compound b , positron emission tomography , dementia , medicine , pathology , disease
analysis. Results: In the early AD dementia group, we found a significantly increased DBSI-derived edema fraction, suggesting the presence of vasogenic edema in several WM regions (tapetum was chosen as a representative example, Fig. 1A). Significantly reduced DBSI-derived axial diffusivity suggested the presence of axonal injury at this early AD dementia stage (Fig. 1B). In comparison, the significantly increased DTI-derived axial diffusivity suggested the failure of DTI to detect axonal injury, probably due to the confounding effect of vasogenic edema (Fig. 1B, red arrow). DTI-/DBSI-derived radial diffusivity and FA increased (Fig. 1C) and decreased (Fig. 1D), respectively, in the early AD dementia group, suggesting demyelination and white matter abnormality. However, DBSI-derived radial diffusivity and FAwere not affected by vasogenic edema contamination and therefore reflected the white matter integrity with higher specificity and accuracy. Conclusions: Our data suggest that DBSI can separately quantify WM structural abnormalities and vasogenic edema in early symptomatic AD. In comparison, conventional DTI cannot separate the effect off WM abnormality from edema, limiting its usage in accurately characterizing the complicated pathological substrates in AD.