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P3‐319: Cognitive Preservation and Change Across Three Waves in Mild Alzheimer’S Disease and Non‐Demented Controls
Author(s) -
Watts Amber,
Johnson David Kevin,
Vidoni Eric D.,
Mahnken Jonathan D.,
Burns Jeffrey M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1983
Subject(s) - psychology , cognition , audiology , verbal memory , dementia , neuropsychology , structural equation modeling , effects of sleep deprivation on cognitive performance , cognitive decline , episodic memory , developmental psychology , medicine , disease , psychiatry , mathematics , statistics
0.01 and delayed recall F(3,70) 1⁄4 3.51, p < 0.05) whilst GRN scores are comparable to HC. GRN patients performed on the other hand significantly lower on visuoconstructive ability than either HC or MAPT and C9orf72 (F(3, 64) 1⁄4 5.06, p < 0.01). Conclusions:These results indicate that MAPT, GRN and C9orf72 mutation carriers differ to the same amount from HC at the typical FTD domains, but distinction between the mutations can be made when comparing less typical FTD domains, namely memory and visuoconstruction. This could enable us to examine NPA as biomarker for upcoming clinical trials.