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IC‐P‐166: Olfactory Sensory Neuron Monitoring in Alzheimer’s Disease: Toward Human Translation of a Pet Imaging Agent
Author(s) -
Van de Bittner Genevieve C.,
Riley Misha M.,
Cao Luxiang,
Ehses Janina,
Wey Hsiao-Ying,
Neelamegam Ramesh,
Albers Mark,
Hooker Jacob M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.197
Subject(s) - tauopathy , neurodegeneration , neuroscience , olfaction , olfactory system , sensory system , population , disease , medicine , psychology , pathology , environmental health
ity was associated with hippocampal volume in medial temporal and limbic regions, with total WM lesion load in a frontal-parietal pattern, and with cortical thickness in a widespread fashion (Figures 2 & 3). Conclusions: The WM quality procedure demonstrated here is a sensitive metric of tissue deterioration in AD showing widespread alterations compared to WM lesion load. The pathologic basis of this new metric is unknown, but we speculate that it reflects vascular integrity based on its relationship with WM lesions, as well as Wallerian degeneration due to upstream gray matter atrophy. Future work will assess limitations of these procedures as well as advance the implementation through addition of partial volume correction to account for regional atrophy.