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P3‐295: Blood Pressure Indices are Associated with Increased Reduced Hippocampal Volume and White Matter Hyperintensities in Hispanic Adults: the Maracaibo Aging Study
Author(s) -
Melgarejo Jesus D.,
Lee Joseph H.,
Narkhede Atul,
Chavez Carlos A.,
Pirela Rosa V.,
Leendertz Reinier,
Terwilliger Joe,
Maestre Gladys E.,
Brickman Adam M.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1959
Subject(s) - hyperintensity , blood pressure , medicine , cardiology , confounding , pulse pressure , white matter , magnetic resonance imaging , radiology
on days1, 5 and 9, respectively. However, there was no significant difference in SBP with the PDE4 inhibitor treatment in both hypertensive models. Rats with repeated treatment of rolipram before acquisition trial (T1) explored the object significantly more than the familiar one during discrimination trial (T2) respectively, showing an increase in memory retention. These effects of repeated administration of centrally acting anti-hypertensive drug were qualitatively similar to those obtained with the hypertensive control rats. Further, HT significantly down regulated the protein expression of pCREB and BDNF in the hippocampus. Repeated treatment with PDE4 inhibitors showed up regulation of pCREB as well as BDNFwhen compared to the vehicle treated group. On the contrary, pCREB and BDNF expressions were further down regulated during treatment with clonidine. Conclusions:These results suggest that rolipram ameliorate HT-induced impairment of learning and memory functions despite no changes in BP. However treatment with clonidine does not alleviate HT-inducedmemory loss despite reduction in BP because of a negative impact on cAMP/PK/CREB signaling. This caveat may be important in designing treatments for memory disorders associated with HT as they are not linked to a single pathophysiological mechanism.