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P3‐294: Effect of a Centrally Acting Anti Hypertensive Drug, Clonidine, on Hypertension‐Induced Cognitive Impairment in Rats
Author(s) -
Jabaris Sobhana George Sugin Lal,
Chidambaram Saravana Babu,
Lakshmi Seetha,
Shridhar Narayanan
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1958
Subject(s) - medicine , clonidine , hippocampus , endocrinology , spontaneously hypertensive rat , agonist , dementia , blood pressure , receptor , disease
lence of vascular cognitive disorder and easily impact the morbidmortality in elderly people. Methods:Case report of a sixty-seven year-old-man with chronic hypertension that developed cognitive and depressive symptoms after an ischemic brain injury, followed by stroke, despite having no motor deficits. Magnetic Resonance Imaging showed lacunar infarction in the right prefrontal c ortex, atrophy of frontal-temporal lobes and discreet myelin thinning (figs. 1 and 2). Within 3 months after the vascular event, the patient showed persistent memory impairment, visuospatial deficits, lack of insight and depressed mood. Instruments applied: Cambridge Mental Disorders of the Elderly Examination (CAMDEX), Neuropsychiatric Inventory (NPI), and Mini Mental Status Examination (MMSE). The diagnosis was made based on a psychiatric interview and considered as a vascular depression with cognitive deficits. Results:The treatment with antidepressants was poorly effective, not achieving remission. Therefore, donepezil and citalopram were combined in order to control cognitive and mood symptoms. After three months, a successful treatment achieved remission of depression and improvement in cognitive and functional impairment. After all, the patient received the diagnosis of VascularMild Cognitive Impairment (VMCI), with multiple impaired domains, and was evaluated once a year, during a six years follow-up, until his death by Acute Myocardial Infarction. In the last interview, the patient still maintained his functionality and cognitive stability, according to neuropsychological evaluation (Pictures). Conclusions:The result obtained in this case report brings new evidences of the diagnosis and treatment of vascular cognitive disorders. Randomized controlled trials are needed in order to confirm the positive effect of the addition of a cholinesterase inhibitor to antidepressants in the treatment of VMCI.