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P3‐275: Increased TAU PET Signal Associated with Longitudinal Mr Atrophy in Cognitively Normal Older Adults
Author(s) -
LaPoint Molly R.,
Chhatwal Jasmeer P.,
Sepulcre Jorge,
Cosio Danielle M.,
Johnson Keith,
Sperling Reisa A.,
Schultz Aaron P.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1938
Subject(s) - atrophy , entorhinal cortex , temporal lobe , medicine , parahippocampal gyrus , posterior cingulate , psychology , pathology , cortex (anatomy) , neuroscience , hippocampus , epilepsy
(CSF Ab1-42>869) Ab pathology (Fig.1). We then ran general linear models to assess CSF proteins and AD markers using age as a covariate. We measured hippocampal volume (adjusted for intracranial volume) as an important indicator of brain integrity. We relied on total score from the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), and self-report of the participant’s memory compared to 20 years ago to indicate objective and subjective cognitive status respectively. Results:The association between levels of Ab1-42 and P-tau was clearly dependent on APOE-e4 status (interaction p<0.01, Fig. 2). In e4 carriers, we observed an expected relationship of higher Ab pathology (lower CSF values) with higher P-tau, but the inverse was found in non-carriers. The association between lower hippocampal volume and higher CSF P-tau was driven by participants with Ab pathology (interaction p1⁄40.017, Fig. 3). The association between higher P-tau and the presence of a subjective cognitive complaint was also driven by individuals with Ab pathology (interaction, p1⁄40.04). There was no interaction between Ab groups and P-tau on cognitive performance, although total RBANS score declines with elevated P-tau (p1⁄40.013, Fig. 4). Conclusions:Our results suggest that in cognitively normal elderly at risk of AD, individuals with both high P-tau and low Ab1-42 levels already present associations between CSF measurements and brain integrity or subjective cognitive assessment. Ab1-42 and P-tau CSF markers, when used conjointly, might therefore be valuable markers to identify candidates for preventive trials.