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P3‐274: High CSF TAU is Related to Reduced Hippocampal Volume and Subjective Cognitive Decline in Healthy Elderly with Amyloid Pathology
Author(s) -
Binette Alexa Pichet,
Vogel Jacob W.,
Fonov Vladimir S.,
Tremblay-Mercier Jennifer,
Madjar Cécile,
Breitner John C.S.,
Collins Louis,
Poirier Judes,
Villeneuve Sylvia
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1937
Subject(s) - cerebrospinal fluid , medicine , apolipoprotein e , hippocampal formation , dementia , cohort , pathology , alzheimer's disease , psychology , oncology , disease
based multiple regression analysis was used to determine regions of significant correlation between multimorbidity score and rCBF. To assess the contributions of individual disease states to the overall pattern of compromised rCBF, each condition of the multimorbidity score was correlated with rCBF in the regions associated with overall multimorbidity score.Results:Several regions showed a relationship between higher multimorbidity scores and levels of brain activity measured by rCBF. Participants with higher scores showed lower activity in orbitofrontal cortex, superior frontal gyrus and temporal pole, and greater activity in posterior superior/ middle temporal gyrus, superior occipital gyrus, cuneus and cerebellum. Anemia, hypertension, diabetes and chronic kidney disease individually contributed to this overall pattern of compromised activity, particularly in anterior and lateral temporal lobe regions. Conclusions:Higher multimorbidity scores were associated with a widespread pattern of compromised brain function. Decreased brain activity was seen in anterior regions and increased activity was seen in posterior regions. These regions play a role in cognitive function, suggesting that the presence of multiple diseases may lead to increased vulnerability to cognitive decline in the future. Anemia, hypertension, diabetes, and chronic kidney disease independently correlated with rCBF in temporal lobe regions of compromised brain activity, suggesting that there may also be regional vulnerability to some disease states.