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P3‐271: Differential Association of Blood Insulin and Hba1C with Cerebral Amyloid Deposition and Regional Glucose Metabolism in Middle‐ and Old‐Aged Adults
Author(s) -
Byun Min Soo,
Kim Hyun Jung,
Yi Dahyun,
Choi Hyo Jung,
Baek Hyewon,
Lee Jun Ho,
Choe Young Min,
Sohn Bo Kyung,
Kim Jee Wook,
Lee Younghwa,
Ko Hyunwoong,
Han Na Young,
Lee Seung Hoon,
Ko Kang,
Woo Jong Inn,
Lee Dong Young
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1934
Subject(s) - precuneus , posterior cingulate , insulin resistance , medicine , parahippocampal gyrus , insulin , endocrinology , positron emission tomography , temporal lobe , nuclear medicine , psychiatry , cognition , epilepsy
typical YCN (n1⁄434) and AD (n1⁄445) subjects using data from the Global Alzheimer’s Association Interactive Network (GAAIN). The second step was to employ linear regression to convert florbetapir and PiB SUVr to the Centiloid scale. Results:Replicate analysis of GAAIN PiB data resulted in mean SUVr for YCN (n1⁄434) of 1.00460.048 and AD (n1⁄445) of 2.06760.204 (R 0.997, slope 0.996, intercept -0.002). Our independent study showed that SUVr values (n1⁄446) for florbetapir and PiB were correlated (R 1⁄4 0.900). The regression equating florbetapir SUVr by the Joshi et al method to PiB SUVr by the Klunk et al method was y 1⁄4 0.514x + 0.451 and appeared to support a linear relationship between the two tracers (Figure 1). The average YCN SUVr for florbetapir (0.9860.07) and PiB (1.0160.03), were converted to 1.51612.06 and 0.3262.61 Centiloids, respectively. 74 YCN florbetapir scans from a previous study (Clark et al, 2011), with average SUVr of 0.9660.04 were converted to Centiloids using the same regression equations yielding an average of -1.6067.59 Centiloids. Applied to the same study, a threshold of approximately 22 Centiloids, 3 SD above the young controls, was optimal for distinguishing cases with neuropathologically verified no/sparse vs moderate to frequent plaques. Conclusions:These findings provide for conversion of florbetapir SUVr to Centiloids, potentially allowing improved tracer independent amyloid quantitation.