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P3‐264: Using White Matter Seed Regions Produces Stronger and More Complex Structural Networks in Healthy Elderly Subjects and Subjects with Alzheimer’S Disease
Author(s) -
Zajac Lauren,
Koo Bang-Bon,
Killiany Ronald
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1927
Subject(s) - region of interest , diffusion mri , white matter , artificial intelligence , computer science , voxel , pattern recognition (psychology) , neuroimaging , magnetic resonance imaging , neuroscience , medicine , psychology , radiology
tau pathology in these diseases. Areas of regional agreement between decreased [F]FDG uptake and increased [F]THK5317 retention were also observed. Conclusions: [F]THK5317, a tauspecific PET tracer, can image the expected extent and regional distribution of tau pathology in patients clinically diagnosed with nonAD dementia. Imaging in vivo tau pathology in conjunction with the use of existing biomarkers for amyloid-beta deposition and neurodegeneration provides a promising tool for exploring the underlying pathology in different dementia syndromes.