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P3‐260: Simultaneous Quantification of White Matter Abnormalities and Vasogenic Edema in Early Alzheimer's Disease
Author(s) -
Wang Qing,
Wang Yong,
Shimony Joshua S.,
Owen Christopher J.,
Liu Jingxia,
Fagan Anne M.,
Cairns Nigel J.,
Ances Beau,
Morris John C.,
Benzinger Tammie LS.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1923
Subject(s) - fractional anisotropy , diffusion mri , white matter , medicine , pathology , dementia , edema , nuclear medicine , magnetic resonance imaging , disease , radiology
significantly greater ePVS volume and counts, but not size, in the WM and BG. After adjusting for covariates on MANCOVA: (1) AD men showed greater WM-ePVS volumes (F1⁄4 7.92, p1⁄4.005) and counts (F1⁄47.49, p1⁄4.007), but not size and (2) in NC, no ePVS sex differences were found. Conclusions:After adjusting for potential mediating variables, ePVS sex differences are maintained only in the white matter for AD. Interestingly, this sex difference only occurs for total volume and count, indicating that men with AD may have a greater number of ePVS, rather than larger ePVS. All ePVS sex differences in normal elderly, and BG-PVS in AD, may be mediated by differences head size, global cognitive functioning (AD), atrophy (NC), and small vessel disease burden. Greater WM-ePVS volumes and counts in AD men may be the result of other, unknown mediating variables still requiring investigation.