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P3‐258: Resting State Functional Mri in Alzheimer’S Disease: an Innovative Approach ror Robust Extraction of the Default Mode Network
Author(s) -
Struyfs Hanne,
Terzopoulos Vasilis,
De Belder Frank,
Parizel Paul M.,
Van Hecke Wim,
Engelborghs Sebastiaan,
Smeets Dirk
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1921
Subject(s) - spatial normalization , default mode network , voxel , normalization (sociology) , artificial intelligence , population , resting state fmri , robustness (evolution) , pattern recognition (psychology) , atrophy , computer science , brain atlas , computer vision , medicine , functional connectivity , neuroscience , psychology , pathology , biology , biochemistry , environmental health , sociology , anthropology , gene
showing widespread alterations compared to WM lesion load. The pathologic basis of this new metric is unknown, but we speculate that it reflects vascular integrity based on its relationship with WM lesions, as well as Wallerian degeneration due to upstream gray matter atrophy. Future work will assess limitations of these procedures as well as advance the implementation through addition of partial volume correction to account for regional atrophy.