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P3‐255: PET TAU Imaging with AV‐1451 in Microtubule‐Associated Protein TAU ( MAPT ) Mutation Carriers Relative to Alzheimer’S Disease Dementia and Controls
Author(s) -
Boeve Bradley F.,
Jones David T.,
Lowe Val J.,
Wiste Heather J.,
Senjem Matthew L.,
Kantarci Kejal,
Knopman David S.,
Dheel Christina,
Wszolek Zbigniew,
Rademakers Rosa,
Petersen Ronald C.,
Jack Clifford R.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1918
Subject(s) - tau protein , frontotemporal dementia , parkinsonism , dementia , tau pathology , neuroscience , mutation , psychology , alzheimer's disease , progressive supranuclear palsy , medicine , pathology , disease , genetics , biology , gene
cerebral lymphatics, and WMH may signify brain lymphatic dysfunction. The purpose of this study was to investigate whether focal WMH were spatially related to intramedullary vessels, and to track their dynamic characteristics by observing any change over one year on MRI. Methods: Focal WMH in periventricular and deep white matter were evaluated in 40 AD (age1⁄475) and 20 healthy elderly (age1⁄472) using co-registered 3D-T1 and T2weighted MR images. A focal WMH was considered as perivascular if it was centered around or overlapped with an intramedullary vessel (Fig1). Intramedullary vessels were defined as linear hypointense signals on appropriately windowed 3D-T1 images. Based on the intramedullary vascular anatomy, a vessel was classified as arteriolar if it was near the cortex or as venular if it connected to the lateral ventricles. Each focal WMH was classified as (enlarging, shrinking or unchanged) between time1 and time 2 (mean 1.3 year apart). Results:A total of 758 focal WMH were identified on the baseline scans from all subjects. 715 (94.3%) focal WMH were perivascular, including 206(28.8%) arteriolar-related and 403(56.4%) venular-related. Of the 715 perivascular focal WMH in the baseline, 209(29.2%) increased, 49(6.9%) decreased and 457(63.9%) were unchanged in size at follow-up (Fig2). These characteristics did not differ between AD and healthy elderly. Conclusions:Focal non-lacunar WMH were mostly centered around intramedullary vessels, suggesting perivascular distribution and were more often associated with venules, than arterioles. The change in size over time raises the possibility the focal WMH may represent perivascular edema/leakage, reflecting underlying dysfunction of perivascular lymphatic drainage. Based on the known increase in arteriolosclerosis and venous collagenosis in aging, we suggest that in aging and dementia small vessel disease may be damaging not only from vascular occlusion but also dysfunction of perivascular clearance of fluid and toxic metabolites.