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P3‐229: Observed Similar Findings of 123 I‐Mibg Myocardial Scintigraphy in DLB/PD znd Rem Sleep Behavior Disorder (RBD), but not in Other Neurodegenerative Disorders
Author(s) -
Seto Makiko,
Nakata Ruka,
Yuasa Takayuki,
Nakao Yoko,
Ichinose Katsuhiro,
Tomita Itsuro,
Satoh Hideyo,
Satoh Akira,
Ochi Makoto,
Tsujihata Mitsuhiro,
Yoshimine Yuji,
Seto Shinji,
Kondoh Hideaki
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2016.06.1891
Subject(s) - dementia with lewy bodies , progressive supranuclear palsy , medicine , parkinsonism , stage (stratigraphy) , scintigraphy , parkinson's disease , atrophy , gastroenterology , cardiology , nuclear medicine , disease , dementia , paleontology , biology
temporal dementia (FTDbv), traumatic encephalopathy, depression with anxiety and non-AD mild cognitive impairment (MCI). PETCT scan had clinical impact in all cases by altering therapeutic management in 6 (46%) and confirming proposed management plan in the remaining 7 patients (53%). It was a conclusive investigation in 12 out of 13 cases. Only one person required further diagnostic tests after amyloid PET-CT (FDG-PET). The time from referral to diagnosis varied between 6 and 39 months, with the shorter intervals observed in more recently referred patients who had access to amyloid imaging. The number of the investigations, including structural imaging (MRI), FDG-PET, CSF analysis and neuropsychological assessment varied between 1 (usually MRI) to 5 (including sequential neuropsychological assessments). Conclusions: This data indicates FFlorbetapir-PET-CT has a significant impact on the confidence of referring clinicians in all cases by altering therapeutic management in 46%, and confirming clinical impression in the others. Amyloid imaging can be a useful technique in diagnostically challenging cases where differential diagnosis includes AD in community memory clinic setting. The considerable cost of the scans may be offset by reducing the time from referral to diagnosis and the number of tests needed to confirm it.